Iyini I-Jujube Seed Extract?
Ukukhishwa kwembewu ye-Jujube kuyisici esisebenzayo esitholakala esitshalweni sendabuko saseShayina i-Ziziphus jujuba var. spinosa ngokusebenzisa ubuchwepheshe besimanje bokukhipha. Isebenzisa inqubo yokukhipha{2}}yezinga lokushisa eliphansi kakhulu, ilondoloza ngokuphelele ama-cyclopeptides ahlukile nama-flavonoid glycosides. Eyaziwa ngokuthi "i-Oriental Sleep Berry", lesi siqephu semvelo sesiyisixazululo sesayensi sokuthuthukisa ikhwalithi yokulala.
Izingxenye Ezibalulekile Ze-Bioactive Nezindlela
Ama-jujubosides
Isebenza ngokukhethekile i-GABA-Ama-receptors (40-60% ukukhuphuka kokuhambisana)
Ilawula ukusebenza kwe-axis ye-hypothalamic-pituitary{1}}adrenal (HPA)
Ivimbela ama-neurons e-glutamatergic ajabule kakhulu
I-Flavonoid Glycosides
Iqeda ubuthongo-ama-free radicals ahlobene nokuphazamiseka
Yandisa amazinga obuchopho 5-HT (25-30% ukuphakama)
Ivikela ama-hippocampal neurons emonakalweni we-oxidative
Ama-Cyclopeptides
Isakhiwo esiyingqayizivele somjikelezo-ontathu sithuthukisa ukungena kwe-BBB
Inweba{0}}ubude bokulala obunensayo (35-45 imizuzu ukukhuphuka)
Imodela izakhi zewashi le-circadian (Iwashi, i-Bmal1).
Izinzuzo Ezifakazelwe Ngokomtholampilo
Ukuthuthukiswa Kwekhwalithi Yokulala
I-50-60% yokunciphisa i-latency yokuqala kokulala
Ukusebenza kahle kokulala kukhuphuke kwaba ngaphezu kwama-85%
70-80% wehla ekuvukeni ebusuku
I-Anxiolytic Effects
Yehlisa amazinga e-cortisol yamathe (ukwehla okungama-30-35%)
Ithuthukisa izinkomba zokushaya kwenhliziyo (HRV).
Yehlisa izimpawu ze-Generalized Anxiety Disorder (GAD).
Imisebenzi ye-Neuroprotective
Ivimbela -i-amyloid aggregation (40-50% ukuncishiswa)
Ithuthukisa ipulasitiki ye-synaptic
Ithuthukisa ukuphazamiseka kwengqondo okumaphakathi (MCI)
Imihlahlandlela yokusebenzisa
Umthamo: 200-400mg/day (10% jujubosides)
Okuthathwe kangcono: imizuzu engu-30 ngaphambi kokulala ngamanzi afudumele
Isifundo: Imiphumela ebalulekile ngemva kwamaviki angu-2-4
Izinyathelo zokuzivikela
▲ Gwema ukusebenzisa kanyekanye nama-sedative
▲ Isexwayiso ezigulini ezine-hypotensive
▲ Ukuqapha ukusebenza kwesibindi okuvamile -ukusetshenziswa isikhathi eside
Izinkomba Zekhwalithi
① Okukhulu noma kulingana no-10% okuqukethwe kwe-jujuboside (i-HPLC iqinisekisiwe)
② Ubuchwepheshe obugcwele- bokukhipha i-spectrum
③ Izinsalela zensimbi/isibulala-zinambuzane-isitifiketi samahhala
Ubufakazi bomsebenzisi
"Ngemuva kwamaviki amabili, iminyaka yami-ubunzima bokulala isikhathi eside baba ngcono kakhulu" - 42isikhulu esiphezulu
"80% ukuncipha kokuvuka ebusuku okubangelwa ukushisa kokuya kokuya esikhathini" - 50yomsebenzisi wesifazane
